Scientists find antibody “roadmap” to AIDS vaccine

From: Judy Miriga

Good people,

Which is why, you people of Luo Nyanza must stop letting your spears be victims of “the Cut” ….. the result of “the cut” is catastrophic as much as it is divastating…….You will have no one to blame because you were warned well in good time….the people of Luo Nyanza will blame no one for love gone haywire….. it is because life must go on if you decide to be stupid. You will never know the secret of the value of “Not to Cut”.

aaaand you will never understand why beautiful Luo Women will not want to look at you twice……..all you will be left with is, go cry to bottomless pit………Please understand that the “Un-Cut” has no relation to curing or prevention of Aids.

For engagement, awareness and to better serve you,
visit the link http://socioeconomicforum50.blogspot.com
for more info and updates…..

Judy Miriga
Diaspora Spokesperson
Executive Director
Confederation Council Foundation for Africa Inc.,
USA
http://socioeconomicforum50.blogspot.com

– – – – – – – – – – –

— On Thu, 4/4/13, Nelson Oreje wrote:
From: Nelson Oreje
Subject: Scientists find antibody “roadmap” to AIDS vaccine
Date: Thursday, April 4, 2013, 8:20 AM

😉
Only the paranoid survive

From: ROSE KAGWIRIA
Date: Thu, 4 Apr 2013 05:17:16 -0700 (PDT)
Subject: Scientists find antibody “roadmap” to AIDS vaccine

Hehehehehe. Nelson. you can only achieve this by remaining single. Anything in twos cannot be trusted including your own hands, eyes, legs etc. Can you imagine how many times your own hands cheat one another even when you are in deep sleep? This is why we say” never trust the hand you did not sleep on”. At least you are assured your head was lying on it. The other one, mosquitoes might have been celebrating on.

From: Geoffrey Omollo
Sent: Thursday, April 4, 2013 1:43 PM
Subject: Scientists find antibody “roadmap” to AIDS vaccine

Have you tried?

Subject: Scientists find antibody “roadmap” to AIDS vaccine
From: nelsonoreje@ . . .
Date: Thu, 4 Apr 2013 10:38:53 +0000

Fidelity will never be adhered to
Only the paranoid survive

From: Geoffrey Omollo
Date: Thu, 4 Apr 2013 11:48:53 +0300
Subject: Scientists find antibody “roadmap” to AIDS vaccine

Rose,

How about the greatest solution of all – moral rectitude, fidelity in marriage an stuff.

Date: Thu, 4 Apr 2013 11:45:50 +0300
Subject: Scientists find antibody “roadmap” to AIDS vaccine
From: ikirimakagwiria@ . . .

Scientists find antibody “roadmap” to AIDS vaccine
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By AFP
Posted Thursday, April 4 2013 at 05:33
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Where there is will, there hope. If small pox was eleminated thru vaccines, even HIV will. God help these scientists to save the world. I have all hopes. In 70s, 80s and 90s, syphilis and gonorrhea were the order of the day where one would find the whole family from house girl to children, their father and mother all infected. Thank God with modern treatment and health education, these diseases are now rare. So why not HIV in the next few years? read more
http://www.nation.co.ke/News/africa/Scientists-find-antibody-roadmap-to-AIDS-vaccine/-/1066/1739004/-/10dcbot/-/index.html

PARIS,

Scientists on a quest for an antibody-based AIDS vaccine said Wednesday they found promising clues in the uncommonly “robust” natural immune response of a patient in Africa.

Studying blood samples over a three-year period after the person was infected, researchers were witness to a microscopic battle between the virus and antibodies — both evolving as they sought to gain the upper hand.

For the first time, scientists were able to follow the full chain of events leading to the patient naturally producing broadly neutralising antibodies (BnAbs)– so called because they attack different strains of the human immunodeficiency virus (HIV) that causes AIDS.

“The current research… fills gaps in knowledge that have impeded development of an effective vaccine for a virus that has killed more than 30 million people worldwide,” said a statement from Duke Medicine, which participated in the study by a team of researchers in the United States and Malawi.

“We learned from this individual how the antibodies get induced with the hope that this information can be a map for how to induce these antibodies as a preventive vaccine,” added team leader Barton Haynes, director of Duke University’s Human Vaccine Institute.

Antibodies are the foot soldiers of the immune system, latching onto viruses or microbial intruders and tagging them for destruction by specialised “killer” cells.

Most antiviral vaccines are made by priming antibodies to recognise germs, but the method has not yet been successful in AIDS control.

One of vaccine developers’ fiercest foes, the HIV virus typically evolves too fast to ever be left open to antibody attack.

The individual in the study, from an African country that is not specified, is one of about 20 per cent of HIV-infected people whose immune systems naturally produce BnAbs.

Unfortunately, this generally only happens two to four years after infection and is of no help to the host who will still develop AIDS if not treated with anti-retroviral drugs.

“When broad neutralising antibodies are made they are no help to the person already infected. The notion is however; if they are present before infection, then they can prevent infection and prevent insertion of the virus genetic material into the host genetic material,” Haynes told AFP of the research published in the journal Nature.

In monkeys, BnAbs have shown to prevent infection.

A BnAbs-based vaccine is being keenly pursued in the battle against AIDS, an immune system-wrecking disease first recognised in 1981.

Almost one per cent of the world’s population today is infected with HIV, according to the United Nations.

In this study, researchers isolated an antibody named CH103, and found that it was triggered by a specific protein envelope found on an early, little-mutated form of the HIV virus.

This meant the antibodies may only be stimulated to respond in the presence of this protein or other similar ones on the virus.

While most antibodies require about 10 to 15 mutations to be able to attack their target, potent BnAbs show 40 to 100, said a comment on the study also published by Nature, which described the findings as a possible “roadmap” to an HIV vaccine.

The CH103 antibody had a much lower number of mutations, which may explain how it developed so quickly in this patient.

The scientists said they had gained a “critical insight” for developing a potential vaccine.

“We are now making recombinant forms of the (protein) envelopes from this patient as a vaccine to immunise animals to recreate the induction of a similar type of antibody,” said Haynes.

A Nature statement said it remained to be seen whether or not the finding could be used to develop an effective vaccine.

“But it presents a strong and testable rationale that can be used to address the major challenges of creating an antibody-based HIV-1 vaccine,” it said.


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